ביוגרפיה
Dr. Mrass received an M.D. degree in 2000 from the University of Vienna.
הצהרה אישית
Dr. Mrass’s work focuses on dissecting the molecular cues that regulate the behavior of T cells in the context of inflammatory tissue environments. He was the first to visualize cytotoxic T cells within the tumor microenvironment with intravital two-photon imaging. This approach provided new insights into the molecular mechanisms that regulate cytotoxic T cell behavior in situ within cancer tissue. For example, CD44 enhances the migratory speed of cytotoxic T cells within the tumor tissue and reduces the time needed for T cells to locate target cancer cells. Dr. Mrass is also studying the behavior of cytotoxic T cells in inflamed or infected lung tissue. This work has revealed a novel ROCK-dependent intermittent migration pattern that balances extensiveness and thoroughness of T cell search during acute lung injury. Currently, he uses a similar model to dissect the molecular mechanisms that regulate the biological activity of cytotoxic T cells in situ within influenza-infected lungs.
https://www.ncbi.nlm.nih.gov/myncbi/paulus.mrass.1/bibliography/public/
תחומי התמחות
תאי T ציטוטוקסיים
דלקת
Tumor microenvironment
Two-photon imaging
Ifluenza
הישגים ופרסים
2004“T cell migration to and within tumors”, Max Kade Postdoctoral Fellowship, (US$ 38,000);
2005-2009“Visualizing T cell Immune Responses Within the Tumor Microenvironment”, Cancer Research Institute Postdoctoral Fellowship, (US$ 120,000);
2009-2014“Direct visualization of T cell-tumour stromal cell interactions to dissect the molecular mechanisms of immune system-mediated tumour destruction” Cancer Institute New South Wales: Career Development and Support Fellowship- Future Research Leaders (Aus$ 1.2 million), Chief Investigator;
2008-2010“Mechanisms of T cell migration and interactions in tumours” (Aus$ 578,250), Chief Investigator B (together with Wolfgang Weninger, Centenary Institute), NHMRC Project Grant.
2011-2013“Real-time Analysis of Tumour-Infiltrating T Cells Using Novel Analytical Tools” (Aus$ 340,000). Chief Investigator A. ARC Discovery Project.
2011-2013“Granzyme B and lymphocyte mobility”, Chief Investigator B (together with Phil Bird, Monash University, Melbourne). NHMRC Project Grant.
2012- 2014“Analysis Of Killer T Cell Geometry During An Anti-Tumour Response” (Aus$ 528,675). Chief Investigator A. NHMRC Project Grant.
2014“Quantitative Analysis and Modeling of T Cell Behavior During an Influenza Infection” ($ 25,000). Fellowship. Spatiotemporal Modeling Center (NIGMS-funded National Center for Systems Biology).
2018-19“In situ imaging of T cells during immunotherapy of ovarian cancer.” ($9,965). UNM Comprehensive Cancer Center Shared Resource Pilot Project.
2019-20“Metabolic reprogramming to induce ovarian cancer immunity” ($6,500). Autophagy, Inflammation and Metabolism (AIM) Pilot Award (P20GM121176).
2019-20“Targeting of Metabolism to Boost Ovarian Cancer Immunity” ($25,000). SOM Research Allocation Committee.
פרסומים מרכזיים
מאמר בכתב עת
Mrass, Paulus, Oruganti, S, R Fricke, G, M Tafoya, J, Byrum, J, R Yang, L, Hamilton, S, L Miller, Miryam, Moses, M, E Cannon, Judy, 2017 ROCK regulates the intermittent mode of interstitial T cell migration in inflamed lungs. Nature communications, vol. 8, Issue 1, 1010
מאמר בכתב עת
Mrass, Paulus, Kinjyo, I, Ng, L, G Reiner, S, L Puré, E, Weninger, W, 2008 CD44 mediates successful interstitial navigation by killer T cells and enables efficient antitumor immunity. Immunity, vol. 29, Issue 6, 971-85
מאמר בכתב עת
Mrass, Paulus, Takano, H, Ng, L, G Daxini, S, Lasaro, M, O Iparraguirre, A, Cavanagh, L, L von Andrian, U, H Ertl, H, C Haydon, P, G Weninger, W, 2006 Random migration precedes stable target cell interactions of tumor-infiltrating T cells. The Journal of experimental medicine, vol. 203, Issue 12, 2749-61
מאמר בכתב עת
Thompson, E, A Mitchell, Jessica, Beura, L, K Torres, D, J Mrass, Paulus, Pierson, M, J Cannon, Judy, Masopust, D, Fife, B, T Vezys, V, 2019 Interstitial Migration of CD8?? T Cells in the Small Intestine Is Dynamic and Is Dictated by Environmental Cues. Cell reports, vol. 26, Issue 11, 2859-2867.e4
מאמר בכתב עת
Chang, J, T Palanivel, V, R Kinjyo, I, Schambach, F, Intlekofer, A, M Banerjee, A, Longworth, S, A Vinup, K, E Mrass, Paulus, Oliaro, J, Killeen, N, Orange, J, S Russell, Samantha, Weninger, W, Reiner, S, L 2007 Asymmetric T lymphocyte division in the initiation of adaptive immune responses. Science (New York, N.Y.), vol. 315, Issue 5819, 1687-91
מין
זכר
שפות
- גרמנית
- אנגלית
קורסים נלמדים
2014-BioMed 514: Immunobiology: lectures on regional immunity and discussion of papers with students
2016-BioMed 505: Special Topics in Biomedical Sciences: lecture on new findings relevant for immune response to infection.
2017-Discussion of immunologically relevant “mini-cases” with medical students.
2017-BioMed 625: Advanced Topics in Immunology and Microbiology (journal club) : organizer
מחקר ומלגות
P. Obeidy, L. A. Ju, S. H. Oehlers, N. S. Zulkhernain, Q. Lee, J. L. Galeano, Nino, R. Kwan, S. Tikoo, L. L. Cavanagh, P. Mrass, A. Cook, S. P. Jackson, M. Biro, B. Roediger, M. Sixt and W. Weninger. 2019. Partial loss of actin nucleator Actin Related Protein 2/3 activity triggers blebbing in primary T lymphocytes. 2020. Immunol Cell Biol. 98:93-113.
E. A. Thompson, J. S. Mitchell, L. K. Beura, D. J. Torres, P. Mrass, M. J. Pierson, J. L. Cannon, D. Masopust, B. T. Fife and V. Vezys. 2019. Interstitial Migration of CD8 alpha beta T Cells in the Small Intestine Is Dynamic and Is Dictated by Environmental Cues. Cell Rep 26:2859-2867 e4.
P. Mrass, S. R. Oruganti, G. M. Fricke, J. Tafoya, J. R. Byrum, L. Yang, S. L. Hamilton, M. J. Miller, M. E. Moses and J. L. Cannon. 2017. ROCK regulates the intermittent mode of interstitial T cell migration in inflamed lungs. Nat Commun 8:1010.
This paper identified a ROCK-dependent intermittent migration pattern of lung-infiltrating T cells that balances extensiveness and thoroughness of T cell search.
P. Mrass, I. Kinjyo, L. G. Ng, S. L. Reiner, E. Pure and W. Weninger. 2008. CD44 mediates successful interstitial navigation by killer T cells and enables efficient antitumor immunity. Immunity 29:971-85.
This paper identified CD44 as a molecular mechanisms that enhances search by tumor-infiltrating T cells for cancer cells, which is essential for optimal cancer immunity.
P. Mrass, H. Takano, L. G. Ng, S. Daxini, M. O. Lazaro, A. Iparraguirre, L. L. Cavanagh, U. H. von Andrian, H. C. Ertl, P. G. Haydon and W. Weninger. 2006. Random migration precedes stable target cell interactions of tumor-infiltrating T cells. J Exp Med 203:2749-61.